Nutritional support

 

Ready-to-Use Supplementary Food (RUSF) - Lipid-based Nutrient Supplement (LNS)

100 g individual sachet [568 kcal]

Nutritional support for HIV+ adults under antiretroviral therapy

2 sachets / day / adult

Covers the increased needs in the main vitamins and minerals and provides 1 163 kcal and 45.4 g of proteins.

Quotation request

Why use Plumpy’UP™ when on antiretroviral therapy?

Plumpy'UP™ is specifically designed for the nutritional support of adults with HIV who are on antiretroviral therapy whose daily food intake does not contain the macronutrients and micronutrients they need.

1) Because people living with HIV who start their therapy have special nutritional needs

People living with HIV have increased nutritional needs. Poor nutritional status at initiation of antiretroviral treatment (ART) is associated with adverse treatment outcomes and high mortality during the early phase of ART.

2) Because Plumpy’UP™ was developed based on studies that have shown great acceptability and efficacy results.

Plumpy’Up™ is developed based on a study conducted in Ethiopia (ARTfood study), showing:

  • a gain in weight, lean body mass and grip strenght, for a 3 months supplementation at the start of ART,
  • a good acceptability by the majority of participants, motivated by a strong wish to get well.

3) Because Plumpy’UP™ is a ready-to-use food supplement that can easily integrate a health program.

  • Easy to stock and easy to distribute
  • Easy to eat, on the spot or mixed with the food
  • A non stigmatizing neutral packaging, that can be carried everywhere

Plumpy’UP™ is a supplementary food and is not a substitute for a varied and nutritious diet.

Main nutritional values

Plumpy’UP™ formula: elements for 100 g*
Energy 568 kcal Selenium 26 µg Vitamin B12 2.4 µg
Proteins 22.7 g Manganese 0.9 mg Vitamin K 55 µg
Lipids 38.5 g Vitamin A 500 µg Biotin 30 µg
Calcium 500 mg Vitamin D 5 µg Folic Acid 400 µg
Magnesium 110 mg Vitamin E 7.5 mg Pantothenic acid 5 mg
Zinc 3 mg Vitamin C 50 mg Niacin 14 mg
Copper 1.5 mg Vitamin B1 1.1 mg    
Iron 4.5 mg Vitamin B2 1.1 mg    
Iodine 55 µg Vitamin B6 1.3 mg    

*The values given in this table are based on Nutriset's knowledge of the intrinsic nutrient content of the raw materials and their variability, as well as the variability of the process. Values may vary.

Clinical trials investigating the role of micronutrient and macronutrient supplementation in relation to Antiretroviral treatment (ART) of HIV patients

Several clinical trials have investigated the role of micronutrient and macronutrient supplementation on HIV-related treatment outcomes:

  • Lancet HIV: RUSF impact has been tested on HIV patients starting ART. Afters 24 weeks these immunocompromised patients receiving a RUSF in clinics in Kenya, Malawi, Uganda and Zimbabwe had greater gains of weight, BMI and mid-upper arm circumference versus the control group.
  • ARTfood: this trial in Ethiopia highlighted the fact that at the start of ART a 3-months’ lipid based nutrient supplementation was leading to a gain in weight, lean body mass and grip strength.
  • NUSTART: a significant increase in CD4 cell counts resulted from a supplementation in vitamins and minerals during a trial in Tanzania and Zambia.
  • In Malawi under-nourished HIV patients starting ART supplemented with RUSF during 14 weeks showed increased weight and lean mass compared to the patients supplemented with Corn-Soy Blend (CSB).

These scientific findings support initiatives in favor of the nutritional support ofpatients with HIV, particularly during the onset phase of their anti-retroviral treatment, because it may increase lean mass, hasten physical and functional recovery, and improve work capacity as well as quality of life.

Plumpy’UP™ is developed based on one of the supplements tested in the ARTfood study.

 

References

Mallewa J et al. Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial. Lancet HIV 2018; Volume 5, No. 5, e231–e240, May 2018.

Mette FO et al. Effects of nutritional supplementation for HIV patients starting antiretroviral treatment: randomised controlled trial in Ethiopia. BMJ, 2014; 348:g3187.

Team NS et al. Effects on mortality of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: a randomised controlled trial. BMC Med 2015; 13: 17.

Ndekha MJ et al. Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial. BMJ 2009; 338: b1867.